Publications
A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation
Arun Padmanabhan, T Yvanka de Soysa, Angelo Pelonero, Valerie Sapp, Parisha P Shah, Qiaohong Wang, Li Li, Clara Youngna Lee, Nandhini Sadagopan, Tomohiro Nishino, Lin Ye, Rachel Yang, Ashley Karnay, Andrey Poleshko, Nikhita Bolar, Ricardo Linares-Saldana, Sanjeev S Ranade, Michael Alexanian, Sarah U Morton, Mohit Jain, Saptarsi M Haldar, Deepak Srivastava, Rajan Jain
Nature Cardiovascular Research, 2024 (Link to manuscript)
Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis
Michael Alexanian#, Arun Padmanabhan, Tomohiro Nishino, Joshua G. Travers, Lin Ye, Clara Youngna Lee, Nandhini Sadagopan, Yu Huang, Angelo Pelonero, Kirsten Auclair, Ada Zhu, Barbara Gonzalez Teran, Will Flanigan, Charis Kee-Seon Kim, Koya Lumbao-Conradson, Mauro Costa, Rajan Jain, Israel Charo, Saptarsi M. Haldar, Katherine S. Pollard, Ronald J. Vagnozzi, Timothy A. McKinsey, Pawel F. Przytycki, Deepak Srivastava
#Denotes corresponding author
bioRxiv, 2023 (Link to preprint)
Transcriptional plasticity of fibroblasts in heart disease
Rudi Micheletti and Michael Alexanian#
#Denotes corresponding author
Biochemical Society Transactions, 2022 (Link to manuscript)
Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes
Tomohiro Nishino, Sanjeev S. Ranade, Angelo Pelonero, Benjamin J. van Soldt, Lin Ye, Michael Alexanian, Frances Koback, Yu Huang, Nandhini Sadagopan, Arun Padmanabhan, Reuben Thomas, Joke G. van Bemmel, Casey A. Gifford, Mauro W. Costa, Deepak Srivastava
bioRxiv, 2022 (Link to preprint)
Single Cell Epigenetics Reveal Cell-Cell Communication Networks in Normal and Abnormal Cardiac Morphogenesis
Sanjeev S. Ranade, Sean Whalen, Ivana Zlatanova, Tomohiro Nishino, Benjamin van Soldt, Lin Ye, Angelo Pelonero, Langley Grace Wallace, Yu Huang, Michael Alexanian, Arun Padmanabhan, Barbara Gonzalez-Teran, Pawel Przytycki, Mauro W. Costa, Casey A. Gifford, Brian L. Black, Katherine S. Pollard, Deepak Srivastava
bioRxiv, 2022 (Link to preprint)
Targeting transcription in heart failure via CDK7/12/13 inhibition
Austin Hsu, Qiming Duan, Daniel S. Day, Xin Luo, Sarah McMahon, Yu Huang, Zachary B. Feldman, Zhen Jiang, Tinghu Zhang, Yanke Liang, Michael Alexanian, Arun Padmanabhan, Jonathan D. Brown, Charles Y. Lin, Nathanael S. Gray, Richard A. Young, Benoit G. Bruneau & Saptarsi M. Haldar
Nature Communications, 2022 (Link to manuscript)
Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes
Gonzalez-Teran B, M Pittman, F Felix, D Richmond-Buccola, R Thomas, K Choudhary, E Moroni, G Colombo, M Alexanian, B Cole, K Samse-Knapp, M McGregor, CA Gifford, R Huttenhain, BD Gelb, BR Conklin, BL Black, BG Bruneau, NJ Krogan, KS Pollard, D Srivastava
Cell, 2022 (Link to manuscript)
KLF15 Cistromes Reveal a Hepatocyte Pathway Governing Plasma Corticosteroid Transport and Systemic Inflammation
Zhen Jiang, Selma Z. Elsarrag, Qiming Duan, Edward LaGory, Zhe Wang, Michael Alexanian, Sarah McMahon, Ingrid C. Rulifson, Sarah Winchester, Yi Wang, Christian Vaisse , Jonathan D. Brown, Mattia Quattrocelli, Charles Y. Lin, Saptarsi M. Haldar
Science Advances, 2022 (Link to manuscript)
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids
Ana C Silva, Oriane B Matthys, David A Joy, Mara A Kauss, Vaishaali Natarajan, Michael H Lai, Diwakar Turaga, Andrew P. Blair, Michael Alexanian, Benoit G Bruneau, Todd C McDevitt
Cell Stem Cell, 2021 (Link to manuscript)
A Transcriptional Switch Governs Fibroblast Activation in Heart Disease
Michael Alexanian, Pawel F Przytycki, Rudi Micheletti, Arun Padmanabhan, Lin Ye, Joshua G Travers, Barbara Gonzalez Teran, Qiming Duan, Sanjeev S Ranade, Franco Felix, Ricardo Linares-Saldana, Yu Huang, Gaia Andreoletti, Jin Yang, Kathryn N Ivey, Rajan Jain, Timothy A McKinsey, Michael G Rosenfeld, Casey Gifford, Katherine S Pollard, Saptarsi M Haldar, Deepak Srivastava
Nature, 2021 (Link to manuscript)
Conserved epigenetic regulatory logic infers genes governing cell identity
Woo Jun Shim, Enakshi Sinniah, Jun Xu, Burcu Vitrinel, Michael Alexanian, Gaia Andreoletti, Sophie Shen, Yuliangzi Sun, Brad Balderson, Carles Boix, Guangdun Peng, Naihe Jing, Yuliang Wang, Manolis Kellis, Patrick PL Tam, Aaron Smith, Michael Piper, Lionel Christiaen, Quan Nguyen, Mikael Bodén, Nathan J Palpant
Cell Systems, 2020 (Link to manuscript)
BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes
Arun Padmanabhan#, Michael Alexanian#, Ricardo Linares-Saldana#, Bárbara González-Terán, Gaia Andreoletti, Yu Huang, Andrew J Connolly, Wonho Kim, Austin Hsu, Qiming Duan, Sarah AB Winchester, Franco Felix, Juan A Perez-Bermejo, Qiaohong Wang, Li Li, Parisha P Shah, Saptarsi M Haldar, Rajan Jain, Deepak Srivastava
#Denotes shared co-first authorship
Circulation, 2020 (Link to manuscript)
Long Noncoding RNAs in Cardiac Development
Michael Alexanian#, Samir Ounzain
#Denotes corresponding author
Cold Spring Harbor perspectives in biology, 2020 (Link to manuscript)
BETs that cover the spread from acquired to heritable heart failure
Michael Alexanian, Saptarsi M Haldar
The Journal of Clinical Investigation, 2020 (Link to manuscript)
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation
Matthew S. Stratton, Rushita A. Bagchi, Marina B. Felisbino, Rachel A. Hirsch, Harrison E. Smith, Andrew S. Riching, Blake Y. Enyart, Keith A. Koch, Maria A. Cavasin, Michael Alexanian, Kunhua Song, Jun Qi, Madeleine E. Lemieux, Deepak Srivastava, Maggie P.Y. Lam, Saptarsi M. Haldar, Charles Y. Lin, Timothy A. McKinsey
Circulation Research, 2019 (Link to manuscript)
Epigenetic therapies in heart failure
M Alexanian, A Padmanabhan, TA McKinsey, SM Haldar
Journal of Molecular and Cellular Cardiology, 2019 (Link to manuscript)
The cardiac myofibroblast: from supporting cast to leading role?
M Alexanian, SM Haldar
Circulation Research, 2019 (Link to manuscript)
A transcribed enhancer dictates mesendoderm specification in pluripotency
Michael Alexanian, Daniel Maric, Stephen P Jenkinson, Marco Mina, Clayton E Friedman, Ching-Chia Ting, Rudi Micheletti, Isabelle Plaisance, Mohamed Nemir, Damien Maison, Jasmin Kernen, Iole Pezzuto, Dominic Villeneuve, Frédéric Burdet, Mark Ibberson, Stephen L Leib, Nathan J Palpant, Nouria Hernandez, Samir Ounzain, Thierry Pedrazzini
Nature Communications, 2017 (Link to manuscript)
The long noncoding RNA Wisper controls cardiac fibrosis and remodeling
Rudi Micheletti, Isabelle Plaisance, Brian J Abraham, Alexandre Sarre, Ching-Chia Ting, Michael Alexanian, Daniel Maric, Damien Maison, Mohamed Nemir, Richard A Young, Blanche Schroen, Arantxa González, Samir Ounzain, Thierry Pedrazzini
Science Translational Medicine, 2017 (Link to manuscript)
New Lncs to mesendoderm specification
M Alexanian, T Pedrazzini, S Ounzain
Journal of Thoracic Disease, 2017 (Link to manuscript)
CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis
Samir Ounzain, Rudi Micheletti, Carme Arnan, Isabelle Plaisance, Dario Cecchi, Blanche Schroen, Ferran Reverter, Michael Alexanian, Christine Gonzales, Shi Yan Ng, Giovanni Bussotti, Iole Pezzuto, Cedric Notredame, Stephane Heymans, Roderic Guigó, Rory Johnson, Thierry Pedrazzini
Journal of Molecular and Cellular Cardiology, 2015 (Link to manuscript)
Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs
Samir Ounzain, Rudi Micheletti, Tal Beckmann, Blanche Schroen, Michael Alexanian, Iole Pezzuto, Stefania Crippa, Mohamed Nemir, Alexandre Sarre, Rory Johnson, Jérôme Dauvillier, Frédéric Burdet, Mark Ibberson, Roderic Guigo, Ioannis Xenarios, Stephane Heymans, Thierry Pedrazzini
European Heart Journal, 2015 (Link to manuscript)
Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease
Samir Ounzain, Iole Pezzuto, Rudi Micheletti, Frédéric Burdet, Razan Sheta, Mohamed Nemir, Christine Gonzales, Alexandre Sarre, Michael Alexanian, Matthew J Blow, Dalit May, Rory Johnson, Jérôme Dauvillier, Len A Pennacchio, Thierry Pedrazzini
Journal of Molecular and Cellular Cardiology, 2014 (Link to manuscript)
